Town Hall: Advances in Cancer Diagnostics and Treatment

Thursday, September 28, 2017 at 5:30 PM
Pancoe-NSUHS Life Sciences Pavilion, Abbott Auditorium
2200 Campus Drive, Evanston, IL

Join us to discuss the next wave of cancer therapies.
Moderated panel discussion and an audience Q&A.

Panel

Jonathan D. Licht, MD
Director, University of Florida Health Cancer Center
Marshall E. Rinker, Sr. Foundation and David B. and Leighan R. Rinker Chair
Professor of Medicine, Biochemistry and Molecular Biology
University of Florida

Lucy A. Godley, MD, PhD
Professor of Medicine – Hematology/Oncology
Cancer Research Center, Committee on Cancer Biology
University of Chicago

Thomas Meade, PhD
Eileen M. Foell Professor of Cancer Research
Professor of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, Radiology
Northwestern University

Carole Baas, PhD
National Advocate, Physical Sciences-Oncology Network, Division of Cancer Biology, National Cancer Institute
Founding Editor, Convergent Science Physical Oncology

Parking
Please download the parking map of the Evanston campus. The panel will take place in Pancoe which is located below #122 on the map. You may park in #122, #118 or #105.

Questions
Please contact Penelope Johnson.

Supported by National Cancer Institute 5U54CA193419-03

Workshop: Translating Cancer Research Innovations

Thursday, July 20, 1:00 PM – 4:00 PM
Pancoe-NSUHS Life Sciences Pavilion, Abbott Auditorium

Register Here

Registration is appreciated but not necessary to attend.

Presentations

A Strategic Approach to Clinical Development: Development of Sutent
William Q. Sargent, PhD
President, SGT Medical Consultants, LLC

Small Molecule Discovery and Development
Atul Jain, PhD
Center for Molecular Imaging and Drug Discovery

Advancing an Orphan Drug to Market
Chandler Robinson, MD
Monopar Therapeutics, LLC

A New Frontier for Mass Spectrometry-Based Applications in Translational Research
Nebiyu Abshiru, PhD
Northwestern Proteomics

Refreshments will be served.

This workshop is supported by NIH/NCI U54CA193419

Feb. 6 Seminar: Jose Onuchic, Rice University – Can Theory Help Cancer Biology?

4:00 – 5:00 pm – Pancoe Auditorium – Monday, Feb. 6

José Nelson Onuchic

Center for Theoretical Biological Physics and Departments of Physics and Astronomy, Chemistry, and Biosciences

Rice University, Houston, Texas

The Genetics and Biophysics of Epithelial-Mesenchymal Transition (EMT): Can Theory Help Cancer Biology? 

Understanding epithelial-mesenchymal transitions during cancer metastasis remains a major challenge in modern biology. Thanks to the rapidly growing body of cell behavior observations and progress in mapping the key regulatory genetic networks associated with these decisions, it is now confirmed that the genetic network that regulates the epithelial-mesenchymal transitions is also able to create an epithelial-mesenchymal hybrid phenotype (E/M). These hybrid cells possess mixed epithelial and mesenchymal characteristics, enabling specialized capabilities such as collective cell migration. On the gene network level, it is now understood that the coexistence of and transitions between the different phenotypes are regulated by a decision unit composed of two highly interconnected chimeric modules: the miR-34/SNAI and the miR-200/ZEB mutual inhibition feedback circuits.   A new tractable theoretical framework to model and decode the operating principles governing these decision units will be presented. This approach connects between the knowledge about intracellular pathways and observations of cellular behavior, and advances towards understanding the logic of cancer decision making. Finally we devise a mechanism-based theoretical model that links cell–cell communication via Notch-Delta-Jagged signaling with the regulation of EMT. We demonstrate that while both Notch-Delta and Notch-Jagged signaling can induce EMT in a population of cells, only Jagged-dominated Notch signaling, but not Delta-dominated signaling, can lead to the formation of clusters containing hybrid E/M cells.