The Dynamic Nucleus of the Cell: Chromatin, Chromosomes and Disease
On June 5, 2013, The Physical Sciences-Oncology Center will host the 2013 H Foundation Basic Science Symposium on the Evanston campus of Northwestern University.
The nucleus is the genetic information storage and processing center of the cell. A human cell nucleus contains 46 chromosomes, containing about 6 billion DNA base pairs, plus all the molecular machines that read, replicate and repair those DNA sequences. Damage to DNA is the root cause of many diseases including many cancers, and our understanding of those diseases requires understanding the basic science of the cell nucleus. At present rapid progress is being made in understanding the nucleus, including methods that for the first time allow us to watch the reading, repair and replication of genes, and understand how the nucleus is organized and reorganized during cell and organism growth. The speakers at this symposium are leading scientists studying the structure and dynamics of genes, chromosomes, and the nucleus, and are laying the basic science groundwork that may lead to development of new approaches to treating cancers and other diseases.
|9:00AM- 9:10AM||Welcome Remarks|
Folding principles of chromosomes
Job Dekker, Ph.D.
|10:00AM- 10:20AM||Coffee Break|
Following single mRNAs from birth to death in living cells: New insights into how cells regulate gene expression
Robert Singer, Ph.D.
Transcriptional regulation through cell-type specific chromosome organization
Ann Dean, Ph.D.
|12:00PM to 1:30PM||Lunch & Poster Session|
Intranuclear positioning and movement of chromosome loci
Andrew Belmont, Ph.D.
Cohesin promotes translation
Jennifer Gerton, Ph.D.
|3:10PM to 3:30PM||Coffee Break|
Random monoallelic expression and transcriptional compensation
David Spector, Ph.D.
Regulating global mRNA levels: the roles of Myc and of promoter DNA melting
David Levens, M.D., Ph.D.
We are looking for posters related to all aspects of gene regulation and chromosome organization. If you are an interested graduate student or postdoc that would like to present a poster at the symposium, please send an email with your abstract to psoc [at] northwestern [dot] edu.
The symposium will be held at the Norris University Center, 1999 Campus Drive, Evanston, IL. View Map
Blocks of rooms have been reserved at both the Hilton Garden Inn and The Homestead Hotel for $145.00 and $95.00 a night, respectively. To make a reservation at the Hilton Garden Inn, please call the hotel direct at 847-475-6400 or toll free through 877-STAY HGI. Please request the Northwestern University H Foundation rate. Reservations at the The Homestead can be made by calling 847-475-3300.
The use of public transportation is encouraged, as visitor parking in limited on the Evanston campus. Both Metra and CTA stops are nearby. Visitor parking passes are required and can be purchased at the Parking Services Office, 1819 Hinman Avenue, or at the parking permit kiosk (credit card only) located near lot #122 on the North end of campus. Please refer to the parking map for eligible visitor parking, and note that visitor parking has been expanded to lot #121 and #122.
If you have any questions, please contact us at psoc [at] northwestern [dot] edu.
|John Marko, Ph.D.
Professor, Molecular Biosciences, Physics & Astronomy
|Steven Kosak, Ph.D.
Assistant Professor, Cell and Molecular Biology, Feinberg School of Medicine
|Jindan Yu, Ph.D.
Assistant Professor, Department of Medicine, Division of Hematology/Oncology