Groundbreaking Work from Dekker Lab
Job Dekker (Project 2) and his colleagues, with support from the CR-PSOC, have just published an important paper in Science on activation of proto-oncogenes by disruption of chromosome neighborhoods. “Activation of proto-oncogenes by disruption of chromosome neighborhoods”. This finding ties to work from Vadim Backman (Project 3, Nanocytometry Core) showing an increase in nanoscale nuclear disorder during carcinogenesis.
See also this link for commentary: http://science.sciencemag.org/content/351/6280/1398?utm_campaign=email-sci-toc&et_rid=33803649&et_cid=364259